Description
The affected

Thermo Fisher Applied Biosystems Genetic Analyzers are vulnerable because .fsa/.hid output files can be edited. An attacker could tamper with these files, altering DNA data and resulting in inaccurate DNA test outcomes.
Published: 2026-08-05
Score: 8.3 High
EPSS: n/a
KEV: No
Impact: n/a
Action: n/a
AI Analysis

Impact

Thermo Fisher Applied Biosystems Genetic Analyzers lack integrity checks for .fsa/.hid output files, enabling an attacker to modify files after they are created. Such tampering can change DNA sequence data read by the analyzer, producing incorrect test results and potentially leading to wrong clinical or forensic conclusions.

Affected Systems

Affected products include Thermo Fisher Applied Biosystems 3500/3500xL Series Data Collection Software (fixed in version 4.0.3), 3730/3730xL Series Data Collection Software (fixed in 5.0.3), SeqStudio Genetic Analyzer Data Collection Software (fixed in 1.2.6), SeqStudio Flex Series Instrument Software (fixed in 1.2.1), and GeneMapper ID‑X Software (fixed in 1.7.4). End‑of‑life products such as 3130 Series, ABI PRISM 3100/3100‑Avant, and ABI PRISM 310 have no updates available.

Risk and Exploitability

The CVSS score of 8.3 reflects high severity; EPSS is not available and the vulnerability is not listed in CISA KEV, suggesting no confirmed public exploitation yet. Exploitation requires the ability to locate and edit .fsa/.hid files, implying local or privileged access to the instrument or the storage where output files reside. An insider or compromised system could use simple file‑editing tools to alter data, after which the analyzer would read the tampered file and generate incorrect DNA interpretation.

Generated by OpenCVE AI on August 5, 2026 at 21:21 UTC.

Remediation

Vendor Solution

Thermo Fisher has developed security updates to address the vulnerability. The security updates implement the use of digital signatures on the instrument software that adds an extralayer of protection. Moving forward, this will help users verify that data files have not been modified. Applied Biosystems 3500/3500xL Series Data Collection Software: Update to version 4.0.3 https://downloads.thermofisher.com/3500_DCS_v4.0.3_Patch/v4.0.3_Patch_Installer.exe Applied Biosystems 3730/3730xL Series Data Collection Software: Update to version 5.0.3 https://downloads.thermofisher.com/3730xl_UDC_v5.0.3_Patch/3730xl_UDC_v5.0.3_Patch.exe Applied Biosystems SeqStudio Genetic Analyzer Data Collection Software: Update to version 1.2.6 https://downloads.thermofisher.com/SeqStudio/1.2.6/SeqStudio-1.2.6.abpkg Applied Biosystems SeqStudio Flex Series Instrument Software: Update to version 1.2.1 https://downloads.thermofisher.com/SeqStudioFlex/1.2.1/SeqStudioFlex-1.2.1.abpkg Applied Biosystems GeneMapper ID-X Software: Update to version 1.7.4 https://downloads.thermofisher.com/GeneMapperID-Xv1.7.4_Patch/GMIDX_v1.7.4_Patch.exe

Vendor Workaround

Applied Biosystems 3130 Series Data Collection Software: Product is End of Life (EoL), no update provided ABI PRISM 3100/3100-Avant Data Collection Software: Product is End of Life (EoL), no update provided ABI PRISM 310 Data Collection Software: Product is End of Life (EoL), no update provided For users who are unable to immediately implement all applicable security updates, Thermo Fisher Scientific recommends implementing the following interim mitigation measures until the applicable updates have been installed:  * Maintain a secure chain of custody for files generated by the HID instrumentation throughout the analysis workflow. * Store generated files on encrypted, password-protected storage media (for example, encrypted USB drives or encrypted hard drives). * Restrict access to generated files to authorized personnel in accordance with your laboratory's access control policies. * Apply the principle of least privilege by limiting user permissions on systems operating the HID instrumentation or hosting associated data analysis and secondary analysis software. * Leverage firewall rules and network access control lists (NACLs) to restrict internet connectivity to only trusted sources. For more information, refer to Thermo Fisher's security bulletin. https://documents.thermofisher.com/TFS-Assets/CORP/Product-Guides/fsa_hid_bulletin.pdf

OpenCVE Recommended Actions

  • Apply the Thermo Fisher security updates for each affected product: download and install the 4.0.3 patch for 3500/3500xL, the 5.0.3 patch for 3730/3730xL, the 1.2.6 package for SeqStudio Genetic Analyzer, the 1.2.1 package for SeqStudio Flex, and the 1.7.4 patch for GeneMapper ID‑X.
  • For instruments that cannot be updated, implement interim controls: maintain a secure chain of custody for all .fsa/.hid files, store them on encrypted media, restrict file access to authorized staff, apply least privilege on systems, and limit network access to trusted sources via firewalls or NACLs.
  • Consider phasing out end‑of‑life products or upgrading to newer instruments that include integrity verification or digital signatures, and review laboratory policies to prevent unauthorized manipulation of sequencing data.

Generated by OpenCVE AI on August 5, 2026 at 21:21 UTC.

Tracking

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Advisories

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History

Wed, 05 Aug 2026 20:45:00 +0000

Type Values Removed Values Added
Description The affected Thermo Fisher Applied Biosystems Genetic Analyzers are vulnerable because .fsa/.hid output files can be edited. An attacker could tamper with these files, altering DNA data and resulting in inaccurate DNA test outcomes.
Title Thermo Fisher Applied Biosystems Genetic Analyzers Missing Support for Integrity Check
Weaknesses CWE-353
References
Metrics cvssV3_1

{'score': 8.4, 'vector': 'CVSS:3.1/AV:L/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H'}

cvssV4_0

{'score': 8.3, 'vector': 'CVSS:4.0/AV:L/AC:L/AT:N/PR:N/UI:N/VC:N/VI:H/VA:H/SC:N/SI:H/SA:N'}

Subscriptions

No data.

cve-icon MITRE

Status: PUBLISHED

Assigner: icscert

Published:

Updated: 2026-08-05T20:23:32.890Z

Reserved: 2026-07-27T15:53:40.951Z

Link: CVE-2026-17583

cve-icon Vulnrichment

No data.

cve-icon NVD

No data.

cve-icon Redhat

No data.

cve-icon OpenCVE Enrichment

Updated: 2026-08-05T21:30:16Z

Weaknesses
  • CWE-353

    Missing Support for Integrity Check